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ESPN Computer Predicts Notre Dame vs. USC Winner

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On Saturday night, No. 6 USC will host No. 15 Notre Dame in a game that may have major College Football Playoff implications. 

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USC will enter this weekend with a 10-1 record. Lincoln Riley's squad is coming off a thrilling 48-45 win over UCLA. 

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Notre Dame, on the other hand, has won five games in a row. Marcus Freeman has done an excellent job of rebounding after an 0-2 start to the season.  

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Even though the Fighting Irish are red-hot heading into Week 12, the Trojans are favored to win, per ESPN's Football Power Index. 

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USC will need Caleb Williams to have another stellar performance this weekend. The Oklahoma transfer has 3,480 passing yards, 33 touchdowns and three interceptions this season. 

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Notre Dame could knock USC out of the playoff picture with a win this Saturday.